Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human CD4
This gene encodes the CD4 membrane glycoprotein of T lymphocytes The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit This gene is expressed not only in T lymphocytes but also in B cells macrophages granulocytes as well as in various regions of the brain The protein functions to initiate or augment the early phase of T-cell activation and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene
ABclonal Technology PE Rabbit anti-Mouse IgG1 mAb
Mouse IgG1 is a subtype of immunoglobulin G antibody that is produced by B cells in response to an antigen It is the most abundant IgG subtype in the serum and plays a crucial role in the adaptive immune response Mouse IgG1 is composed of two heavy chains and two light chains and it is involved in opsonization complement activation and antibody-dependent cell-mediated cytotoxicity It is also involved in the regulation of immune responses including the activation of T cells and the inhibition of B cell activation Mouse IgG1 is widely used in research and diagnostic applications including ELISA Western blotting and immunohistochemistry It is also used in therapeutic applications such as immunotherapy and vaccine development
ABclonal Technology PE Rabbit anti-Mouse CD34 mAb
Enables sulfate binding activity Acts upstream of or within leukocyte migration Located in cytoplasm external side of plasma membrane and extracellular region Is expressed in several structures including alimentary system cardiovascular system extraembryonic component genitourinary system and skin Orthologous to human CD34 (CD34 molecule)
ABclonal Technology CD307b Rabbit mAb
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
ABclonal Technology 647 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 647 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 488 Rabbit anti-Human CD307b
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
ABclonal Technology 594 Rabbit anti-Human CD70
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF27 CD27 It is a surface antigen on activated but not on resting T and B lymphocytes It induces proliferation of costimulated T cells enhances the generation of cytolytic T cells and contributes to T cell activation This cytokine is also reported to play a role in regulating B-cell activation cytotoxic function of natural killer cells and immunoglobulin sythesis
ABclonal Technology Orexin B Rabbit mAb
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides orexin A and orexin B by proteolytic processing Orexin A and orexin B which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2 function in the regulation of sleep and arousal This neuropeptide arrangement may also play a role in feeding behavior metabolism and homeostasis
Abcam Rabbit Anti-Mouse IgG H&L (Alkaline Phosphatase) preadsorbed.
Rabbit Anti-Mouse IgG H&L (Alkaline Phosphatase) preadsorbed.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 488 Rabbit anti-Human SIGLEC9
Predicted to enable monosaccharide binding activity and sialic acid binding activity Predicted to be involved in cell adhesion Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis engulfment Predicted to be located in external side of plasma membrane Predicted to be active in plasma membrane
ABclonal Technology PE Rabbit anti-Human CD94 mAb
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Three transcript variants encoding two different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Mouse IL-13 mAb
Predicted to enable interleukin-13 receptor binding activity Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation Acts upstream of or within cellular response to cytokine stimulus inflammatory response and positive regulation of immune effector process Located in cytoplasm external side of plasma membrane and extracellular space Is expressed in gut liver male reproductive gland or organ and thymus Used to study atopic dermatitis Human ortholog(s) of this gene implicated in several diseases including allergic disease (multiple) autoimmune disease (multiple) diffuse scleroderma lung disease (multiple) and nose disease (multiple) Orthologous to human IL13 (interleukin 13)